Etkin Lab
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Etkin Lab

From Neural Circuits to Novel Solutions



  • Drysdale AT, Grosenick L, Downar J, Dunlop K, Mansouri F, Meng Y, Fetcho R, Zebley B, Oathes DJ, Etkin A, Schatzberg AF, Sudheimer K, Keller J, Mayberg HS, Gunning FM, Alexopoulos GS, Fox MD, Pascual-Leone A, Voss HU, Casey J, Dubin MJ, Lisoton C. “Resting State Connectivity Biomarkers Define Neurophysiological Biotypes of Depression”, Nature Medicine, in press. pdf
  • McTeague LM, Huemer J, Carreon DM, Jiang M, Eickhoff SB, Etkin A. "Identification of Common Neural Circuit Disruptions in Cognitive Control Across Psychiatric Disorders”, American Journal of Psychiatry, in press. McTeague, AJP exec fxn meta across disorders
  • Otte C, Gold S, Pennix B, Pariante C, Etkin A, Fava M, Mohr D, Schatzberg AF. “Major Depressive Disorder”, Nature Reviews Disease Primers, in press
  • McTeague L, Goodkind M, Etkin A. “Transdiagnostic Impairment of Cognitive Control in Mental Illness,” Journal of Psychiatric Research, in press
  • Fournier JC, Chase HW, Greenberg T, Etkin A, Almeida JR, Stiffler R, Deckersbach T, Weyandt S, Cooper C, Toups M, Camody T, Kurian B, Peltier S, Adams P, McInnis MG, Oquendo MA, McGrath PJ, Fava M, Weissman M, Parsey R, Trivedi MH, Phillips ML. “Neuroticism and Individual Differences in Neural Function in Unmedicated Major Depression: Findings from the EMBARC Study”, Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, in press
  • Fonzo GA, Etkin A. “Brain Connectivity Reflects Mental and Physical States in Generalized Anxiety Disorder”, Biological Psychiatry, in press

  • Etkin A, Fonzo GA. “Learning in generalized anxiety disorder benefits from neither the carrot nor the stick”, American Journal of Psychiatry, in press

  • Fonzo GA, Huemer J, Etkin A. “History of Childhood Maltreatment Augments Dorsolateral Prefrontal Processing of Emotional Valence in PTSD”, Journal of Psychiatric Research, in press.pdf
  • Keynan JN, Meir-Hasson Y, Gilam G, Cohen A, Jackont G, Kinreich S, Ikar L, Or-Borichev A, Etkin A, Gyurak A, Klovatch I, Intrator N, Hendler T. “Limbic Activity Modulation Guided by fMRI-Inspired EEG Improves Implicit Emotion Regulation,” Biological Psychiatry, in press pdf
  • Etkin A. “Remember the good times? Biased autobiographical memory in depression.” American Journal of Psychiatry, 173(1):8-9 (2015).pdf
  • Williams LM, Goldstein-Piekarski AN, Chowdhury N, Grisanzo K, Haug NA, Samara Z, Etkin A, O’Hara R, Schatzberg AF, Suppes T, Yesavage J. “Developing a clinical translational neuroscience taxonomy for anxiety and mood disorder: protocol for the baseline-follow up Research domain criteria Anxiety and Depression (“RAD”) project,” BMC Psychiatry, in press. pdf
  • Jiang Y, Oathes D, Hush J, Darnall B, Charvat M, Mackey S, Etkin A. “Perturbed connectivity of the amygdala and its subregions with the central executive and default mode networks in chronic pain”, Pain, in press.
  • Ferenczi EA, Zalocusky KA, Liston C, Grosenick L, Warden MW, Amatya D, Katovich K, Mehta H, Patenaude B, Davidson T, Ramakrishnan C, Kalanithi P, Etkin A, Knutson B, Glover GH, Deisseroth K. “Modulation of global dynamics by local excitability: brainwide multi-region neural activity relationships regulating reward-related behavior”, Science, in press.pdf
  • Fischer AS, Keller CJ, Etkin A. “The clinical applicability of functional connectivity in depression: Pathways toward more targeted intervention,” Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, in press.pdf
  • Shilyansky, C, Williams LM, Gyurak A, Harris A, Usherwood T, Etkin A. “Multiple cognitive impairments associated with depression do not change with antidepressant treatment despite clinical remission: a randomized longitudinal study,” Lancet Psychiatry, in press. pdf


  • Marusak HA, Furman D, Kuruvadi N, Shattuck D, Joshi S, Joshi A, Etkin A, Thomason M. (2015.) Amygdala response to salient social cues vary with oxytocin receptor genotype in youth. Neuropsychologia, 79:1-9. pdf
  • Etkin A, Buchel C, Gross JJ. (2015). The Neural bases of emotion regulation. Nature Reviews Neuroscience, 16: 693-700. pdf
  • Cservenka A, Stroup ML, Etkin A, Nagel BJ (in press). The effects of age, sex, and hormones on emotional conflict-related brain response during adolescence, Brain and Cognition.pdf
  • Deisseroth K, Etkin A, Malenka RC. (in press). Optogenetics and the Circuit Dynamics of Psychiatric Disease, JAMA. pdf
  • Robinson AH, Safer DL, Austin JL, Etkin A. (in press). Does Implicit Emotion Regulation in Binge Eating Disorder Matter? Eating Behaviors.pdf
  • Arns M, Bruder G, Hegerl U, Spooner C, Palmer DM, Etkin A, Fallahpour K, Gatt, J, Hirshberg L, Gordon E (in press). EEG alpha asymmetry as a gender-specific predictor of outcome to acute treatment with different antidepressant medications in the randomized iSPOT-D study, Clinical Neurophysiology. pdf
  • Marusak HA, Etkin A, Thomason ME. (in press). Disrupted insula-based neural circuit organization and conflict interference in trauma-exposed youth, Neuroimage: Clinical. pdf
  • Fung LK, Akil M, Widge A, Roberts LW, Etkin A. (2015). Attitudes towards neuroscience education in psychiatry: a national multi-stakeholder survey, Academica Psychiatry, 39:139-146. pdf
  • Arns M, Etkin A, Hegerl U, William LM, DeBattista C, Palmer DM, Fitzgerald PB, Harris A, deBeuss R, Gordon E. (in press). Frontal and rostral anterior cingulate (rACC) theta EEG in depression: Implications for treatment outcome?, European Neuropsychopharmacology, 25(8):1190-1200. pdf
  • Williams LM, Korgaonkar M, Song Y, Paton R, Goldstein-Pierkarksi A, Eagles S, Grieve S, Harris H, Underwood T, Etkin A. (in press). Amygdala reactivity to emotional faces in the prediction of general and medication-specific responses to antidepressant treatment in the randomized iSPOT-D trial, Neuropsychopharmacology, 40:2398-2408. pdf
  • Miller S, McTeague LM, Gyurak A, Patenaude B, Williams LM, Grieve SM, Korgaonkar MS, Etkin A . (in press). Cognition - Childhood Maltreatment Interactions in the Prediction of Antidepressant Outcomes in Major Depressive Disorder Patients: Results from the iSPOT-D Trial, Depression and Anxiety.pdf
  • Gyurak A, Patenaude B, Korgaonkar MS, Grieve SM, Williams LM, Etkin A. (in press). “Fronto-Parietal Activation During Response Inhibition Predicts Remission to Antidepressants in Patients with Major Depression,” Biological Psychiatry.pdf
  • Phillips ML, Chase HW, Sheline YI, Etkin A, Almeida JRC, Deckersbach T, Trivedi M. (2015). Identifying predictors, moderators, and mediators of antidepressant response in major depressive disorder: neuroimaging approaches. American Journal of Psychiatry, 172(2): 124-138. pdf
  • Marusak HA, Martin KR, Etkin A and Thomason ME. (2015). Childhood trauma exposure disrupts the automatic regulation of emotional processing. Neuropsychopharmacology, in press. pdf
  • Day CV, Gatt JM, Etkin A, DeBattista C, Schatzberg AF, Williams LM. (in press). Cognitive and emotional biomarkers of melancholic depression: An iSPOT-D report, Journal of Affective Disorders, 176:141-150. pdf
  • Schatzberg AF, DeBattista C, Etkin A, Murphy G, Lazzeroni L, Williams LM. (2015). “ABCB1 genetic effects on antidepressant outcomes in the International Study to Predict Optimized Treatment for Depression (iSPOT-D),” American Journal of Psychiatry. pdf
  • Arnow BA, Blasey C, Williams LM, Palmer D, Rekshan W, Schatzberg AF, Etkin A, Kulkarni J, Luther JF, Rush AJ. 2015. Depression Subtypes in Predicting Antidepressant Response: A Report from the iSPOT-D Trial, American Journal of Psychiatry. pdf
  • Etkin A. “Predicting treatment response in post-traumatic stress disorder.” Journal of Clinical Psychiatry, 76(8):e1035-e1036. (2015)pdf
  • Powers A, Etkin A, Gyurak A, Bradley B, Jovanovic T. “Associations Between Childhood Abuse, Posttraumatic Stress Disorder, and Implicit Emotion Regulation Deficits: Evidence From a Low-Income, Inner-City Population,” Psychiatry, 78(3):251-64 (2015).pdf


  • Goodkind M, Eickhoff SB, Oathes DJ, Jiang Y, Chang A, Jones-Hagata LB, Ortega BN, Zaiko YV, Roach EL, Korgaonkar MS, Grieve SM, Galatzer-Levy I, Fox PT, Etkin A. (2014). Identification of a common neurobiological substrate for mental illness. JAMA Psychiatry. Published online February 04, 2015. pdf
  • Saveanu R, Etkin A, Duchemin A-M, Gyurak A, DeBattista C, Schatzberg AF, Sood S, Day C, Wisniewski SR, Palmer DM, Rekshan WR, Galatzer-Levy I, Gordon E, Rush AJ and Williams LM. (in press). The International Study to Predict Optimized Treatment for Depression (iSPOT-D): Outcomes from the acute phase of antidepressant treatment. Journal of Psychiatric Research.pdf
  • Etkin A, Patenaude B, Song YJC, Usherwood T, Rekshan W, Schatzberg AF, Rush AJ, Williams LM. (in press). A Cognitive-Emotional Biomarker for Predicting Remission with Antidepressant Medications: A Report from the iSPOT-D Trial. Neuropsychopharmacology, 40, 1332-1342. pdf
  • Etkin A, Cuthbert B. (2014). Beyond the DSM: Development of a Transdiagnostic Psychiatric Neuroscience Course. Academic Psychiatry, 38(2):145-50. pdf
  • Liston C, Chen AC, Zebley BD, Drysdale AT, Gordon R, Leuchter B, Voss HU, Casey BJ, Etkin A, Dubin MJ. (2014). Default Mode Network Mechanisms of Transcranial Magnetic Stimulation in Depression. Biological Psychiatry, 76(7):517-26.pdf
  • Akil M, Etkin A. (2014). Transforming neuroscience education in psychiatry. Academic Psychiatry, 38(2):116-20. pdf
  • Oathes DJ, Patenaude B, Schatzberg AF, Etkin A. (2014). Neurobiological signatures of anxiety and depression in resting-state fMRI. Biological Psychiatry, 77(4):385-393. pdf
  • Etkin A. (2014). Neuroimaging and the Future of Personalized Treatment in Psychiatry. Depression and Anxiety, 31:899-901. pdf
  • Day CVA, Rush JA, Harris AW, Boyce P, Etkin A, Rekshan W, DeBattista C, Schatzberg AF, Arnow BA, Williams LM (2014). Impairment and distress patterns distinguishing the melancholic depression subtype: An iSPOT- D Report. Journal of Affective Disorders, 174:493-502. pdf
  • Fung LK, Akil M, Widge A, Roberts LW, Etkin A. (2014). Attitudes Toward Neuroscience Education Among Psychiatry Residents and Fellows. Academic Psychiatry, 38(2):127-34. pdf


  • Etkin A, Gyurak A, O’Hara R. (2013). A Neurobiological Approach to the Cognitive Deficits of Psychiatric Disorders. Dialogues in Clinical Neuroscience, 15(4):419-29. pdf
  • Waring, JD, Etkin A, Hallmayer JF, O’Hara R. (2013). Connectivity Underlying Emotion Conflict Regulation in Older Adults with 5-HTTLPR Short Allele: A Preliminary Investigation. American Journal of Geriatric Psychiatry, 22(9):946-50. pdf
  • Korgaonkar, M, Grieve SM, Etkin A, Koslow SH, Williams LM. (2013). Using standardized fMRI protocols to identify patterns of prefrontal circuit dysregulation that are common and specific to cognitive and emotional tasks in major depressive disorder: First wave results from the iSPOT-D study. Neuropsychopharmacology, 38:863–871. pdf
  • Chen AC, Etkin A. (2013). Hippocampal Network Connectivity and Activation Differentiates Post-Traumatic Stress Disorder From Generalized Anxiety Disorder. Neuropsychopharmacology, 38(10):1889-98. pdf
  • Grieve SM, Korgaonkar MS, Etkin A, Harris A, Koslow SH, Wisniewski S, Schatzberg AF, Nemeroff CB, Gordon E, Williams LM. (2013). Brain imaging predictors and the international study to predict optimized treatment for depression: study protocol for a randomized controlled trial. Trials, 14:224. pdf
  • Tzabazis A, Aparici CM, Rowbotham MC, Schneider MB, Etkin A, Yeomans DC. (2013). Shaped magnetic field pulses by multi-coil repetitive transcranial magnetic stimulation (rTMS) differentially modulate anterior cingulate cortex responses and pain in volunteers and fibromyalgia patients. Mol Pain, 9(1):33. pdf
  • Chen AC, Oathes DJ, Chang C, Bradley T, Zhou Z-W, Williams LM, Glover GH, Deisseroth K, Etkin A. Causal interactions between fronto-parietal central executive and default-mode networks in humans. Proceedings of the National Academy of Science, 110(49):19944-9. pdf
  • Jarcho JM, Fox NA, Pine DS, Etkin A, Leibenluft E, Shechner T, Ernst M. (2013). The neural correlates of emotion-based cognitive control in adults with early childhood behavioral inhibition. Biological Psychology, 92(2):306-314. pdf


  • Etkin A. (2012). Neurobiology of Anxiety: From Neural Circuits to Novel Solutions? Depression & Anxiety, 29(5):355–358. pdf
  • Hamilton JP, Etkin A, Furman DJ, Lemus MG, Johnson RF, Gotlib IH. (2012). Functional neuroimaging of Major Depressive Disorder: A meta-analysis and new integration of baseline activation and neural response data. Am J Psychiatry, 169(7):693-703. pdf


  • Etkin A & Schatzberg A. (2011). Common abnormalities and disorder-specific compensation during implicit regulation of emotional processing in generalized anxiety versus major depressive disorders. Am J Psychiatry, 168(9):968–978. pdf
  • Pine DS & Freedman R. (2011). Imaging a Brighter Future [Editorial]. (2011). Am J Psychiatry, 168(9):885-887. pdf
  • Gyurak A, Gross JJ, & Etkin A (2011). Explicit and implicit emotion regulation: A dual-process framework. Cognition and Emotion, 25(3):400-412. pdf
  • Etkin A, Egner T & Kalisch R. (2011). Emotional processing in anterior cingulate and medial prefrontal cortex. Trends in Cognitive Science, 15(2):85-93. pdf


  • Etkin A, Prater K, Hoeft F, Menon V, & Schatzberg A. (2010). Failure of Anterior Cingulate Activation and Connectivity With the Amygdala During Implicit Regulation of Emotional Processing in Generalized Anxiety Disorder. Am J Psychiatry, 167(5):545-554. pdf
  • Ernst M. (2010). Conflict adaptation in generalized anxiety disorder: small paradigm twist, large scientific leap. [Editorial]. (2010). Am J Psychiatry, 167(5):489-492. pdf
  • Mechias ML, Etkin A, & Kalisch R. (2010). A meta-analysis of instructed fear studies: Implications for conscious appraisal of threat. NeuroImage, 49:1760-1768. pdf


  • Etkin A. (2009). Functional Neuroanatomy of Anxiety: A Neural Circuit Perspective. Curr Topics Behav Neurosci, 2:251-277. pdf
  • Etkin A, Prater K, Schatzberg A, Menon V, & Greicius M. (2009). Disrupted Amygdalar Subregion Functional Connectivity and Evidence of a Compensatory Network in Generalized Anxiety Disorder. Arch Gen Psychiatry, 66(12):1361-1372. pdf


  • Egner T, Etkin A, Gale S & Hirsch J. (2008). Dissociable Neural Systems Resolve Conflict from Emotional versus Nonemotional Distracters. Cerebral Cortex, 18:1475-1484. pdf
  • Pittenger C & Etkin A. (2008). Are There Biological Commonalities among Different Psychiatric Disorders. In A. Tasman, J. Kay, J. Lieberman, M. First & M. Maj (Eds), Psychiatry (pp. 243-256). pdf


  • Etkin A & Wager T (2007). Functional Neuroimaging of Anxiety: A Meta-Analysis of Emotional Processing in PTSD, Social Anxiety Disorder, and Specific Phobia. Am J Psychiatry, 164(10):1476-1488. pdf


  • Etkin A, Alarcon JM, Weisberg S, Touzani K, Huang Y, Nordheim A, & Kandel E. (2006). A Role in Learning for SRF: Deletion in the Adult Forebrain Disrupts LTD and the Formation of an Immediate Memory of a Novel Context. Neuron, 50:127-143. pdf
  • Etkin A, Egner T, Peraza D, Kandel E, & Hirsch J. (2006). Resolving Emotional Conflict: A Role for the Rostral Anterior Cingulate Cortex in Modulating Activity in the Amygdala. Neuron, 51:871-882. pdf


  • Etkin A, Pittenger C, & Kandel E. (2005). Biology in the Service of Psychotherapy. In J. Oldham, A. Skodol & D. Bender (Eds), Textbook of Personality Disorders (pp. 669-682). American Psychiatric Publishing. pdf
  • Etkin A, Pittenger C, Polan H, & Kandel E. (2005). Toward a Neurobiology of Psychotherapy: Basic Science and Clinical Applications. J Neuropsychiatry Clin Neurosci, 17(2):145-158. pdf


  • Etkin A, Klemenagen K, Dudman J, Rogan M, Hen R, Kandel E, & Hirsch J. (2004). Individual Differences in Trait Anxiety Predict the Response of the Basolateral Amygdala to Unconsciously Processed Fearful Faces. Neuron, 44:1043-1055. pdf


  • Si K, Giustetto M, Etkin A, Hsu R, Janisiewicz A, Miniaci M, Kim J, Zhu H, & Kandel E. (2003). A Neuronal Isoform of CPEB Regulates Local Protein Synthesis and Stabilizes Synapse-Specific Long-Term Facilitation in Aplysia. Cell, 115:893-904. pdf


  • Reimold AM, Etkin A, Clauss I, Perkins A, Friend DS, Zhang J, Horton HF, Scott A, Orkin SH, Byrne MC, Grusby MJ and Glimcher LH. “An essential role in liver development for transcription factor XBP-1.” Genes & Development, 14(2):152-157 (2000). pdf
  • Etkin A. “Drugs and Therapeutics in the Age of the Genome.” JAMA, 284(21):2786-7 (2000) pdf